Abstract
Ir complexes of chiral phosphine-diamine ligands catalyse the hydrogenation and transfer hydrogenation of aryl-piperidin-4-yl methanones, and ketones bearing both an aryl group and secondary alkyl substituent with up to 98% e.e., and with substrate to catalyst ratios of up to 4000.
Highlights
Enantioselective hydrogenation and transfer hydrogenation of cycloalkyl and heterocyclic ketones catalysed by an iridium complex of a tridentate phosphine-diamine ligand†
The excellent results that are obtained in the reduction of a wide range of acetophenone derivatives using Noyori catalysts of type [RuCl2(diphos)(diamine)] are well known, and these Ru complexes are industrially viable catalysts (Fig. 1, 1)
A case in point is the development of a range of Ru complexes of phosphine diamine and phosphine amino-alcohol ligands (Fig. 1, 2)
Summary
Enantioselective hydrogenation and transfer hydrogenation of cycloalkyl and heterocyclic ketones catalysed by an iridium complex of a tridentate phosphine-diamine ligand†. Ir complexes of chiral phosphine-diamine ligands catalyse the hydrogenation and transfer hydrogenation of aryl-piperidin-4-yl methanones, and ketones bearing both an aryl group and secondary alkyl substituent with up to 98% e.e., and with substrate to catalyst ratios of up to 4000.
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