Abstract
The Michael reaction is one of the most general and versatile methods for carbon-carbon bond formation,1 and its Mukaiyama-Michael variant provides an efficient strategy for the addition of silyl enol ethers to α,β-unsaturated carbonyl compounds.2 Catalytic asymmetric reactions with broad variations in α,β-unsaturated carbonyl compounds and chiral catalyst (Lewis acid and Bronsted acid) are well documented,3,4 and the enantioenriched 1,5-dicarbonyl compounds formed from these reactions have proven to be useful building blocks. However, there has been limited variation in the silyl enol ethers used in these reactions, and none of them have incorporated multiple functional groups.
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