Abstract
In this work, highly elastic and superabsorbent hydrogels of collagen-poly(vinyl pyrrolidone) (PVP)-poly(acrylic acid) (PAA)-poly(ethylene oxide) (PEO) quaternary copolymer were obtained using e-beam crosslinking reaction to be used for soft tissue engineering. This study is focused on the evaluation of rheological, swelling and stability properties under different pH media, offering in the same time an insight on the hydrogel network parameters. Rheological studies confirm that collagen/PVP/PAA/PEO hydrogels present solid behaviour similar with that of most soft tissue as human abdominal fat, skin and dermis and even more of breast gland or brain and liver. Hydrogels revealed superabsorbent capacity, both in deionized water and in simulated biological buffers, 1600% and 4000%. The stability and physical form of hydrogels were maintained for more than 50 h in environments that simulate both the pH of the healthy skin and that of an infected wound. The elastic modulus and the parameters of the network structure of hydrogels showed the formation of hydrogel with permanent network.
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