High-intensity hemoperfusion combined with early long-term CRRT for severe organophosphorus poisoning

Abstract

Objective To investigate the effect of high intensity hemoperfusion combined with continuous renal replacement therapy (CRRT) on patients with severe organophosphorus poisoning. Methods Random number table method was used to divide the 89 patients with severe organophosphorus poisoning into two groups, 44 cases in the control group were given routine perfusion combined with CRRT treatment, and 45 cases in the observation group were given high intensity of hemoperfusion combined with CRRT treatment. The cholinesterase activity, drug use, mechanical ventilation time, hospitalization time, incidence of complications and fatality rate after treatment in the two groups were compared. Results On the 3rd and 5th day after treatment, the cholinesterase activity in the observation group was higher than that in the control group, the dosage of penehyclidine hydrochloride, atropine, and pralidoxime chloride, mechanical ventilation time and hospital stay were lower than those of the control group (P<0.05); in the observation group, the complication rate (15.56%), fatality rate (6.67%) were lower than those in the control group (43.18%, 27.27%), the differences between the two groups were significant (P<0.05). Conclusions The high intensity hemoperfusion combined with CRRT can significantly improve the activity of cholinesterase in patients with severe organophosphorus poisoning. The amount of conventional drugs is less, which is conducive to early removal of respirator, and has higher safety, less hospitalization time and lower mortality. Key words: Continuous renal replacement therapy; High intensity hemoperfusion; Severe organophosphorus poisoning; Safety