Higher baseline tumor necrosis factor [TNF]-a and early postoperative interleukin [IL]-10 level are associated with postoperative sepsis in cardiac surgery: A preliminary study

Abstract

Event Abstract Back to Event Higher baseline tumor necrosis factor [TNF]-α and early postoperative interleukin [IL]-10 level are associated with postoperative sepsis in cardiac surgery: A preliminary study Ben Azaiz Mouna1*, Arbi Riheb1, Romthani Chiheb1, Ghothban Walid1, Haddad Soumaia1, Iabben Iheb1, Kdous Chama1, Shnik Slim1, Ferjani Mustapha1 and Ghazouani Ezzedine1 1 Military hospital tunis, Tunisia Background and aim: Sepsis after cardiac surgery under cardiopulmonary bypass (CPB) is a serious complication. Cytokines are the main and first actors in sepsis(1), therefore the aim of this study was to evaluate pro-inflammatory (IL1, IL-6, IL-8 and TNF-α) and anti-inflammatory (IL-10) cytokin in patients undergoing a CPB as a precocious markers. Methods: Patients undergoing a CPB were enrolled in a prospective clinical study. They were divided in two groups as Septic and non septic patients. The levels of TNFα,IL-6, IL-8, and IL-10 were measured at four different periods (T1: induction, T2: 5 minutes after the end of CBP , T3: 4h after the end of CBP : and T4: 24h post CBP). The CRP was measured at day 1, 3, 6 and 9 after surgery. Results: Nineteen patients were studied. Six patients presented a postoperative sepsis. Only TNF-α at T1 [266.5 UI/ml (9.93; 480) vs. 7.75 UI/ml (6.66; 11.35) in septic vs. non septic patients respectively; p= 0.041] and IL-10 at T3 [6.35 UI/ml (5.37; 6.89) vs. 5 UI/ml (5; 5.01) in septic vs. non septic patients respectively; p= 0.022] were found to be associated with postoperative sepsis.Quantitative variables are expressed as median (Interquartile range). There was no significant difference among CRP measurements. Conclusion: Monitoring of cytokines, mainly TNFα and IL-10, are more reliable markers then CRP in this procedure. Therefore, these cytokines might be a new tools for management of sepsis during CPB.However the sample size in this preliminary study was too small to allow any definitive conclusion. References - Adib-Conquy, M and Cavaillon, J-M. Host inflammatory and anti-inflammatory response during sepsis. Pathologie Biologie. 60 (2012), 306–313. Keywords: Sepsis, Inflammation, Cytokines, cardiopulmonarybypass, interleukin10, Tumor Necrosis Factor-alpha Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013. Presentation Type: Abstract Topic: Innate immunity Citation: Mouna B, Riheb A, Chiheb R, Walid G, Soumaia H, Iheb I, Chama K, Slim S, Mustapha F and Ezzedine G (2013). Higher baseline tumor necrosis factor [TNF]-α and early postoperative interleukin [IL]-10 level are associated with postoperative sepsis in cardiac surgery: A preliminary study . Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.01163 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 15 Jul 2013; Published Online: 22 Aug 2013. * Correspondence: Dr. Ben Azaiz Mouna, Military hospital tunis, tunis, Tunisia, drmouna1@yahoo.fr Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Ben Azaiz Mouna Arbi Riheb Romthani Chiheb Ghothban Walid Haddad Soumaia Iabben Iheb Kdous Chama Shnik Slim Ferjani Mustapha Ghazouani Ezzedine Google Ben Azaiz Mouna Arbi Riheb Romthani Chiheb Ghothban Walid Haddad Soumaia Iabben Iheb Kdous Chama Shnik Slim Ferjani Mustapha Ghazouani Ezzedine Google Scholar Ben Azaiz Mouna Arbi Riheb Romthani Chiheb Ghothban Walid Haddad Soumaia Iabben Iheb Kdous Chama Shnik Slim Ferjani Mustapha Ghazouani Ezzedine PubMed Ben Azaiz Mouna Arbi Riheb Romthani Chiheb Ghothban Walid Haddad Soumaia Iabben Iheb Kdous Chama Shnik Slim Ferjani Mustapha Ghazouani Ezzedine Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.