Abstract
Bone metastases often occur in prostate cancers, lung cancers and breast cancers. Bone alkaline phosphatase (BALP) is one of the most commonly used serological markers for clinical evaluation of bone metabolism. Here, we reported that high concentrations of uric acid (UA) caused decrease of BALP levels and revealed that the effect of high concentrations of UA on the BALP expression was through inhibition of its promoter activity. Our results suggested physicians to think about serum UA status of patients with advanced cancer to avoid misdiagnosis when BALP was used to diagnose or assess the extent of bone metastases.
Highlights
Tumor metastasis is a leading cause of death in patients with advanced cancer [1,2,3]
We reported that high concentrations of uric acid (UA) caused decrease of Bone alkaline phosphatase (BALP) levels and revealed that the effect of high concentrations of UA on the BALP expression was through inhibition of its promoter activity
The results showed the average BALP level of the high-UA individuals was significantly lower than the healthy subjects
Summary
Tumor metastasis is a leading cause of death in patients with advanced cancer [1,2,3]. The gold standard for monitoring metastatic bone involvement, is highly sensitive in the diagnosis of bone metastases [17,18,19,20,21]. It lacks specificity and is not suitable for the patients follow up [22, 23]. Serological detection has the advantages of early diagnosis, rapid detection and easy continuous monitoring [24,25,26,27]
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