Abstract
The triglyceride-glucose (TyG) index has been associated with various metabolic, cardiovascular, and cerebrovascular diseases. We evaluated the association between the TyG index and early recurrent ischemic lesions (ERILs) in patients with acute ischemic stroke (AIS). We included consecutive patients diagnosed with AIS between 2010 and 2016. ERILs were defined as new diffusion-weighted imaging lesions outside the initial symptomatic lesion area. The TyG index was calculated using the following formula: log scale of fasting triglyceride × fasting glucose/2. A total of 176 patients with AIS were evaluated. In the multivariable analysis, the TyG index remained significant (adjusted odds ratio [aOR] 2.63, 95% confidence interval [CI] 1.34–5.15). This close correlation between the TyG index and ERIL was pronounced in ERIL-same group (aOR 2.84, 95% CI 1.40–5.78), but not in ERIL-different group. When comparing the relationship between the TyG index and ERIL by stroke mechanisms, only the intracranial- and extracranial-large artery atherosclerosis groups showed significantly higher TyG index values in patients with ERIL than those without. In conclusion, a higher TyG index was associated with ERIL, especially ERIL-same, in patients with AIS. The TyG index appears to be involved in ERIL occurrence by a mechanism related to atherosclerosis.
Highlights
The triglyceride-glucose (TyG) index has been associated with various metabolic, cardiovascular, and cerebrovascular diseases
The TyG index was correlated with atrial fibrillation, stroke mechanism, white blood cell (WBC) counts, TG/HDL ratio, early recurrent ischemic lesions (ERILs), and ERIL-same (Supplementary Table S2)
We found that the TyG index was closely associated with ERIL, especially ERIL-same, in patients with acute ischemic stroke (AIS)
Summary
The triglyceride-glucose (TyG) index has been associated with various metabolic, cardiovascular, and cerebrovascular diseases. We evaluated the association between the TyG index and early recurrent ischemic lesions (ERILs) in patients with acute ischemic stroke (AIS). Stroke recurrence increases the risk of subsequent disability and mortality in patients with acute ischemic stroke (AIS). Stroke recurrence increases the risk of subsequent disability and mortality in patients with acute ischemic stroke (AIS)1 Identifying these high-risk groups is an important issue in clinical practice. New diffusion-weighted imaging (DWI) lesions, referred to as early recurrent ischemic lesion (ERIL), are frequently observed during the acute period in patients with AIS1,4, occurring in up to 40% of patients in the first week. Fasting glucose and TG are well-known risk factors for stroke r ecurrence, and a recent study has reported that the TyG index, as a comprehensive indicator of acute hyperglycemia and hypertriglyceridemia, is associated with early neurological deterioration (END) in AIS p atients. We compared the relationship between the TyG index and ERIL according to stroke mechanism
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
