Abstract
BackgroundThe aim of the study was to investigate the high-sensitivity troponin T (hs-TnT) release profile in off-pump coronary artery bypass grafting (OPCABG) patients with normal postoperative course.MethodsFrom January 2015 to October 2016, 398 consecutive OPCABG patients who had normal postoperative courses were enrolled. Blood samples for hs-TnT were collected at several time points and the comparisons among different time points grouped by various factors were further analyzed.ResultsThere were 317 male and 81 female patients, with a median age of 64. For 66.1% of the patients, peak hs-TnT occurred at the 24th hour after OPCABG, regardless of the groups divided by different factors. In total, the hs-TnT values were much higher in male group (P = 0.035), in patients who need 5 or more bypass grafts (P = 0.035) and in patients with high-risk EuroSCORE II assessment (P = 0.013). However, we failed to find any significant differences between different age groups (P = 0.129) or among different coronary heart disease classifications (P = 0.191).ConclusionsThe hs-TnT values were affected by various factors and culminated around the first 24 h following OPCABG. It may provide some useful information for future clinical studies of myocardial biomarkers after OPCABG.
Highlights
The aim of the study was to investigate the high-sensitivity troponin T release profile in off-pump coronary artery bypass grafting (OPCABG) patients with normal postoperative course
Three hundred ninety-eight OPCABG patients with normal postoperative course were enrolled in our study
Peak high-sensitivity troponin T (hs-troponin T (TnT)) value occurred at the 24th hour after OPCABG, regardless of the groups divided by different factors
Summary
The aim of the study was to investigate the high-sensitivity troponin T (hs-TnT) release profile in off-pump coronary artery bypass grafting (OPCABG) patients with normal postoperative course. Myocardial cell injury is inevitable after cardiac surgery, leading to the elevation of various cardiac biomarkers. Myocardial infarction (MI), caused by myocardial injury or coronary artery anomaly, is a major cause of disability and death around the world. It has been proved that postoperative serum cardiac troponin T (TnT) level is correlated with increased morbidity and mortality after coronary artery bypass grafting (CABG) [6,7,8]. The new generation hs-TnT could detect minor myocardial injury with higher sensitivity and has been widely used in cardiac surgery
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