Abstract
A novel polarographic method for the determination of coenzyme Q 10 in β-cyclodextrin (β-CD) and iodinate system is proposed. The stability of coenzyme Q 10 to light was improved by the formation of coenzyme Q 10–β-CD inclusion complex. In addition, the sensitivity for the determination of coenzyme Q 10 was enhanced by both the formation and the polarographic catalytic wave of the inclusion complex in the presence of iodinate. In 0.1 mol/L HAc-NaAc (pH 4.7)–5.0 × 10 −5 mol/L β-CD–1.2 × 10 −3 mol/L potassium iodinate–ethanol/water (60:40, v/v) medium, coenzyme Q 10–β-CD inclusion complex yielded a sensitive association/parallel catalytic wave. The second-order derivative peak current of the catalytic wave was proportional to coenzyme Q 10 concentration in the range of 6.0 × 10 −8–2.5 × 10 −7 mol/L, and the detection limit was 1.0 × 10 −8 mol/L. The proposed method has high analytical sensitivity and is allowed to determine coenzyme Q 10 under light.
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