Abstract
Peripherally inserted central venous catheters (PICCs) are widely used in cancer patients. Although PICC is a convenient tool, its use is associated with an obvious increase in the incidence of venous thrombosis. The risk factors for deep vein thrombosis associated with the use of PICCs in cancer patients are largely unexplored. This study aimed to investigate the incidence of PICC-associated thrombosis in lymphoma compared with its incidences in other types of cancer. A total of 8028 adult cancer patients inserted with PICC between June 2007 and June 2015 were included in this study. A total of 249 of the 8028 included patients (3.1%) inserted with PICC developed upper extremity deep vein thrombosis (PICC-UEDVT). Patients with lymphoma were more likely to have PICC-UEDVT than those with other types of malignancies (7.1% vs. 2.80%; P < 0.001). Logistic analysis revealed that a lymphoma diagnosis was a risk factor for UEDVT in cancer patients inserted with PICC (OR: 3.849, 95% CI: 2.334–6.347). Patients with lymphoma may be more predisposed to developing PICC-UEDVT than those with other types of malignancies. Identifying the mechanism underlying the relationship between PICC-UEDVT and lymphoma requires further study.
Highlights
Inserted central venous catheters (PICCs) are vascular access devices that are inserted through a peripheral vein in the arm
Logistic analysis revealed that a lymphoma diagnosis was a risk factor for upper extremity deep vein thrombosis (UEDVT) in cancer patients inserted with Peripherally inserted central venous catheters (PICCs) (OR: 3.849, 95% confidence intervals (CIs): 2.334–6.347)
PICCs are strongly associated with the risk of developing upper extremity deep vein thrombosis (UEDVT) [6, 7], and patients with cancer, especially those with hematological malignancy [8], are at a high risk of developing Venous thromboembolism (VTE) [9]
Summary
Inserted central venous catheters (PICCs) are vascular access devices that are inserted through a peripheral vein in the arm. PICCs are often used to deliver special medications, such as parenteral nutrition, intravenous antimicrobials and anti-carcinogens. They are used to maintain venous access in patients who may require frequent phlebotomies, continuous medication administration and extended courses of chemotherapy [1]. Among the early and delayed complications associated with PICCs, the most notable is thrombosis. PICCs are strongly associated with the risk of developing upper extremity deep vein thrombosis (UEDVT) [6, 7], and patients with cancer, especially those with hematological malignancy [8], are at a high risk of developing VTE [9]
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