Abstract
BackgroundPROX1 is a transcription factor involved in the development of various organs. It has also an important function in colorectal cancer progression. The aim of this study was to investigate the prognostic role of PROX1 expression in gastric cancer.MethodsWe evaluated PROX1 expression in gastric cancer by immunohistochemistry of tumor-tissue microarrays including tumor specimens from 283 patients who underwent surgery at Helsinki University Hospital. We investigated the association of PROX1 expression with clinicopathologic variables and patient survival.ResultsCytoplasmic PROX1 reactivity was high in 56 (20.5%) and low in 217 (79.5%) cases. Low PROX1 immunostaining associated with diffuse cancer type (p = 0.002). In subgroup analysis, PROX1 was a significant marker of better prognosis in patients aged under 66 (p = 0.007), in those with intestinal cancer (p = 0.025), among men (p = 0.019), and in tumors of less than 5 cm diameter (p = 0.030). Patients with high PROX1 expression had a cancer-specific 5-year survival of 65.6% (95% CI 52.7–78.5), compared to 37.1% (95% CI 30.2–44.0) for those with low expression (p = 0.004, log-rank test). This result remained significant in multivariable analysis (HR = 0.56; 95% CI 0.35–0.90; p = 0.017).ConclusionIn gastric cancer, high cytoplasmic PROX1 expression is an independent marker of better prognosis.
Highlights
Gastric cancer is a highly malignant tumor and is globally one of the major causes of cancerrelated death [1]
PROX1 was a significant marker of better prognosis in patients aged under 66 (p = 0.007), in those with intestinal cancer (p = 0.025), among men (p = 0.019), and in tumors of less than 5 cm diameter (p = 0.030)
Patients with high PROX1 expression had a cancerspecific 5-year survival of 65.6%, compared to 37.1% for those with low expression (p = 0.004, log-rank test)
Summary
Gastric cancer is a highly malignant tumor and is globally one of the major causes of cancerrelated death [1]. The transcription factor PROX1 is a key regulatory protein in the development of various organs. It is involved in cell-fate determination and progenitor-cell regulation in the central nervous system, eye, liver, pancreas, lymphatic system, and the heart. It plays a role in cancer development. PROX1 is a transcription factor involved in the development of various organs. It has an important function in colorectal cancer progression. The aim of this study was to investigate the prognostic role of PROX1 expression in gastric cancer
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