Abstract
A high-performance thin layer chromatographic method has been developed for the determination of rosiglitazone in pharmaceutical preparations. This method uses silica gel 60F 254 as the stationary phase, ethyl acetate-toluene-methanol, 45 + 55 + 1 ( v/v ) as mobile phase. Detection was performed at 242 nm and pioglitazone hydrochloride was used as internal standard. The response was found to be linearly dependent on amount of rosiglitazone between 100 and 1200 ng. The method was validated to determine its accuracy and precision. System-suitability tests were conducted to verify that the resolution and reproducibility of the system were adequate for the analysis. The determination of rosiglitazone in tablets is described.
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