Abstract
ObjectivesThe coordinated immune response of the host is the key of the successful combat of the body against SARS-CoV-2 infection and is decisive for the development and progression of COVID-19. In this study, we aimed to investigate whether the immunological phenotype of patients are associated with duration of illness in patients with severe COVID-19.MethodIn this single-center study, 69 patients with severe or critical COVID-19 were recruited retrospectively. Immunological parameters including counts of white blood cells, neutrophils, lymphocytes, the neutrophil-to-lymphocyte ratio, and levels of circulating cytokines and cytokine receptors were screened for their association with disease severity, survival and duration of illness of COVID-19.ResultsOur data confirmed previous results that neutrophil-to-lymphocyte ratio and circulating levels of IL-6 represent prominent biomarker for the prediction of disease severity and survival of COVID-19. However, this study shows for the first time that duration of illness in patients with severe COVID-19 is positively associated with serum levels of IL-8 (P=0.004) and soluble IL-2Rα (P=0.025).ConclusionThe significant association of duration of illness with circulating levels of IL-8 and soluble IL-2Rα in patients with severe COVID-19 implicates that neutrophils and T cells are involved in the evolution of COVID-19.
Highlights
Coronavirus disease 2019 (COVID-19) which was first reported in Wuhan, China is viral pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [1, 2]
Some immunological parameters have been identified as prominent biomarker to predict the severity of the disease and patient survival rates, including neutrophil-to-lymphocytes ratio (NLR) in peripheral blood and circulating levels of interleukin-6 (IL-6) [12,13,14,15]
We investigated whether immunological parameters including immune cells in peripheral blood and circulating cytokines are associated with duration of illness in patients with severe COVID-19
Summary
Coronavirus disease 2019 (COVID-19) which was first reported in Wuhan, China is viral pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [1, 2]. Excessive and dysregulated immune responses can result in inordinate inflammation and harmful tissue damage at both local and systemic levels, causing severe illness [10, 11]. Within this view, some immunological parameters have been identified as prominent biomarker to predict the severity of the disease and patient survival rates, including neutrophil-to-lymphocytes ratio (NLR) in peripheral blood and circulating levels of interleukin-6 (IL-6) [12,13,14,15]. We investigated whether immunological parameters including immune cells in peripheral blood and circulating cytokines are associated with duration of illness in patients with severe COVID-19
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
