Abstract
ObjectivesTo disclose the associated risk factors for latent tuberculosis infection (LTBI) and the current situation of LTBI in the eastern China.MethodsA cross-sectional study was undertaken to evaluate the LTBI rate and risk factors.ResultsA total of 5305 subjects were finally included, with the IGRA positive rate of 19.98% (1060/5305). The LTBI rates were increasing with age (ORs were in significance from 6.60 to 20.92). Male gender significantly increased the risk of LTBI by 0.52 fold (OR = 1.52). Both smoking and drinking significantly increased the risk of LTBI (OR = 1.83 and OR = 1.67, respectively). Meanwhile, overweight and close contact with tuberculosis were risk factors for LTBI (OR = 1.36 and OR = 2.38, respectively). However, higher level of education and BCG vaccination lowered the risk of LTBI (OR = 0.16 and OR = 0.39, respectively). The multivariate logistic regression showed that age, male gender, smoking, overweight and close contacting with tuberculosis were risk factors for LTBI, but BCG vaccination was a protective factor for LTBI.ConclusionsBCG vaccination exerted protective effect on tuberculosis. However, LTBI rate in the Chinese rural area was critical and subjects above 30 years, male, smoking, overweight and close contact with tuberculosis wound be the targets for LTBI screening and source of tuberculosis.
Highlights
Latent tuberculosis infection (LTBI) is defined as a state of persistent mycobacteria-specific Tcell responses without clinical evidence of tuberculosis [1]
The LTBI rates were increasing with age (ORs were in significance from 6.60 to 20.92)
Higher level of education and bacillus Calmette-Guérin (BCG) vaccination lowered the risk of LTBI (OR = 0.16 and odds ratio (OR) = 0.39, respectively)
Summary
Latent tuberculosis infection (LTBI) is defined as a state of persistent mycobacteria-specific Tcell responses without clinical evidence of tuberculosis [1]. China has the second largest number of tuberculosis patients in the world [4]. The LTBI population would potentially contribute to the aggressively increased new tuberculosis incidences and which may be greatly counted on the LTBI rate of the population, especially for the rural areas of China because tuberculosis patients from rural areas accounted for a major proportion of tuberculosis incidences. To accurately elucidate the current LTBI in rural areas of China is of critically important for tuberculosis control. Jiangsu Province was located in the eastern part of China with relatively lower incidence of tuberculosis [5], and it is worthwhile to reveal the situation of LTBI in this area
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
