Abstract
High-Intensity Exercise With Blood Flow Restriction or in Hypoxia as Valuable Spaceflight Countermeasures?
Highlights
Determining effective countermeasures to the physical issues of microgravity, radiation, and isolation is crucial for human space flights (Demontis et al, 2017)
It is applicable to incorporate hypoxic training methods for acclimation with preference of hypobaric hypoxia over normobaric hypoxia due to the risks associated with excessive oxygen in the atmosphere of the space habitat (Millet, in press)
It has been shown that passive hypoxic exposure leads to negligible adaptations in skeletal muscle tissue (Lundby et al, 2009), while the combination of prolonged passive exposure to hypoxia with exercise, high-intensity exercise (Live High-Train Low and High, LHTLH) induces beneficial transcriptional responses, which are not present with passive exposure only (Brocherie et al, 2018)
Summary
Determining effective countermeasures to the physical issues of microgravity, radiation, and isolation (i.e., decreased aerobic capacity and cardiovascular dysfunction, along with muscle atrophy, bone and muscle loss, and hypocapnia) is crucial for human space flights (Demontis et al, 2017). A balance is needed between the barometric conditions of the habitat and the safety threshold of oxygen concentrations due to flammability In this context, it is applicable to incorporate hypoxic training methods for acclimation with preference of hypobaric hypoxia (decreased barometric pressure and oxygen fraction) over normobaric hypoxia due to the risks associated with excessive oxygen in the atmosphere of the space habitat (Millet, in press). The combinations of passive hypoxic exposure as experienced during space flights and high-intensity exercise in hypoxia appear as adequate strategies for improving peak power production and maximal oxygen consumption
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