Abstract
Hepsin, a membrane-associated serine protease, is frequently upregulated in epithelial cancers and involved in cancer progression. Our study aims to describe the expression pattern and evaluate the clinical implication of hepsin in gastric cancer patients. The mRNA expression of hepsin was analyzed in 50 gastric cancer and matched non-tumor tissues, which was downregulated in 78% (39/50) of gastric cancer. By searching and analyzing four independent datasets from Oncomine, we obtained the similar results. Furthermore, we evaluated the hepsin expression by IHC in tissue microarray (TMA) containing 220 Gastric Cancer specimens. More importantly, Kaplan-Meier survival and Cox regression analyses were taken to access the prognosis of gastric cancer and predicted that hepsin protein expression was one of the significant and independent prognostic factors for overall survival of Gastric Cancer.
Highlights
Hepsin, a membrane-associated serine protease, is frequently upregulated in epithelial cancers and involved in cancer progression
The expression pattern and impact of hepsin in gastric cancer remain unclear, so we aim to investigate the correlation between hepsin protein and overall survival (OS) of gastric cancer patients
We explored the association between hepsin expression and overall survival in gastric cancer patients with early or advanced clinical stages and with or without lymphatic metastasis and vascular invasion
Summary
A membrane-associated serine protease, is frequently upregulated in epithelial cancers and involved in cancer progression. Our study aims to describe the expression pattern and evaluate the clinical implication of hepsin in gastric cancer patients. The mRNA expression of hepsin was analyzed in 50 gastric cancer and matched non-tumor tissues, which was downregulated in 78% (39/50) of gastric cancer. Kaplan-Meier survival and Cox regression analyses were taken to access the prognosis of gastric cancer and predicted that hepsin protein expression was one of the significant and independent prognostic factors for overall survival of Gastric Cancer. Most patients diagnosed with gastric cancer at advanced stage have a low 5-year survival rate[3]. The crucial reason for the poor prognosis of the most malignant cancers including gastric cancer is invasion and metastasis[4]. To improve the life quality and survival rate of gastric cancer patients, some novel and effective therapeutic methods must be created and developed
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