Abstract
The effect of high energy carbon ion beam as the modification tool for the multiwalled carbon nanotubes (MWCNT) has been studied. The change in the morphology, length and diameter of the carbon nanotubes upon irradiation is analyzed using Raman spectroscopy, atomic force microscopy and field emission scanning electron microscopy. The irradiated MWCNTs had a diameter in the range of 3–27nm which is much lower in comparison to the diameter of the tubes present in the pristine state. The irradiated MWCNT modified glassy carbon has been further used as a sensor for the electrochemical investigation of deoxyguanosine and deoxyadenosine. A detection limit of 507 and 300nM was observed for deoxyguanosine and deoxyadenosine respectively. The simultaneous determination of the two analytes was performed using the fabricated sensor and its practical utility was tested by analyzing DNA extracted from herring sperm and MCF7 cell line for the presence of deoxyguanosine and deoxyadenosine. The common biomolecules present in blood and urine did not interfere in the determination and a high stability and reproducibility of the sensor was observed.
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