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https://doi.org/10.1016/0021-9150(94)05410-k
Copy DOIJournal: Atherosclerosis | Publication Date: Jan 20, 1995 |
Citations: 9 |
To study dietary fat and cholesterol effects on plasma high density lipoprotein (HDL) metabolism and rates of apolipoprotein (apo) A-I catabolism, guinea pigs were fed 15% ( wt wt ) lard- or corn oil-based diets with 0.01% (basal), 0.08%, 0.17% or 0.33% cholesterol. Absorbed dietary cholesterol provided 6%, 50%, 100% and 200%, respectively, of the daily endogenous cholesterol synthetic mass. While total plasma cholesterol concentrations increased significantly above basal levels at the 0.17% and 0.33% cholesterol intakes, plasma apo E-free HDL (E oHDL) cholesterol concentrations did not increase significantly until the 0.33% cholesterol level ( P < 0.001). Fractional catabolic rates (FCR) of injected [ 131I]-apo A-I were not altered by dietary treatment, either fat saturation or cholesterol, but were inversely correlated with plasma E oHDL cholesterol levels ( r = −0.622), suggestive of a regulatory role of turnover rates on HDL cholesterol levels independent of dietary treatment. Analysis of the high affinity E oHDL binding to isolated hepatic membranes suggested that hepatic binding was not a determinant of HDL catabolism, as dietary cholesterolinduced decreases in B max (binding capacity) were not correlated with changes in apo A-I FCR. Even though dietary cholesterol was associated with increased plasma E oHDL cholesterol and with decreased HDL binding protein B max, these values did not correlate with each other nor with effects on apo A-I FCR.
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