Hidden objective test

Abstract

AbstractBackgroundAlzheimer’s disease patients frequently complaint that they lose things and be unable to find them again because of deficit in visuospatial memory. In this study we aimed to develop a novel visuospatial memory tests called the Hidden Objective Test (HOT) based on the ideas of patients’ complaint. Virtual reality (VR) is an optimal tool for developing this visuospatial memory tests in that real‐life settings implementation.MethodWe designed a pleasant and cozy living room. The photorealistic virtual environment interface with 360‐degree panoramas was rendered through HMD. The VR system enables the users to turn their head, to walk around, to open and close the furniture doors using controllers, and to track their movement in the VR living room. When the participant starts the test, the VR living room is shown and instructions for the prospective memory test are given. Nine items appeared on the white panel in order, and one by one, the item moved to the each furniture space and were hided. Memory test composed of 1) Item Free‐recall test, 2) Place Free‐recall test, 3) Item Recognition test, 4) Place‐item matching test, and 5) Prospective memory test.Participants were selected from those who visited the Memory Disorder Clinic at Samsung Medical Center in Seoul, Korea, between November 1st, 2019 and January 30th, 2020. This study group comprised 16 AD, 15 AMCI, and 15 NC participants.ResultThe performance of memory test was NC>AMCI (p<0.001), AMCI>AD (p<0.05), and NC > AD (p<0.001) in the Item Free‐recall test; NC>AMCI (p<0.01) and NC > AD (p<0.001) in the Place Free‐recall test; NC>AMCI (p<0.05), AMCI>AD (p<0.01), and NC > AD (p<0.001) in the Item Recognition test; NC>AMCI (p<0.001) and NC > AD (p<0.001) in the Place‐item matching test; NC > AD (p<0.05) in the Prospective memory test. Interestingly, the average movement path showed that NC participants went straight toward the target point whereas AD patients wandered to the target point when searching for hidden objects.ConclusionThe Hidden Objective Test (HOT) developed in this study, which incorporated virtual reality to experience real‐life events, showed potential to be used as a new memory screening test.