Abstract
HIGH susceptibility to the neuromuscular blocking action of succinylcholine is usually associated with a defective form of pseudocholinesterase in blood plasma; the abnormal enzyme is distinguished by its resistance to inhibition by dibucaine1. The gene frequency of this abnormality in Caucasians is estimated to be 0.019; 3.8 per cent of the population are heterozygous; and 1 in 2,800 individuals is sensitive to succinylcholine2.
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