Abstract
Here I Am, Despite Myself.
Highlights
Soon after beginning our studies with measles virus infection of neurons, we realized that neuronal viral spread was fundamentally different from the classical spread described in textbooks for other cell types: measles virus resulted in a nonlytic infection in neurons without release of infectious progeny
While a key antiviral cytokine, interferon gamma, is needed for resolution of a neuronal viral infection, as it is for many peripheral infections, the signaling pathways within the neuron is wholly distinct
There are occasions when I wonder if the human intellect has the capacity to fully understand all of life’s mysteries: for example, how memories are retained and recalled, how diverse organs work in concert, or how cellular responses to an external cue are interpreted
Summary
I often will tell students who visit Fox Chase Cancer Center, where I’ve been a faculty member for 20 years, that a common September 10, 2015 misconception about those of us who have been research scientists for some time is that ours was an intentional journey: that perhaps I knew from an early age that I would be a viral neuroimmunologist, and that each step along the way was thoughtfully considered and deliberate.
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