Abstract
Lung cancer represents a major cause of cancer-related death worldwide. Although various tactics and anti-tumor drugs have been used to improve curative effects, five-year survival rate of lung cancer patients remains poor. In this study, we investigated the action and underlying mechanisms of our recently optimized Chinese herbal formula Yangyinjiedu (YYJD) against lung cancer. YYJD significantly inhibits the proliferation of lung cancer cell lines (95-D, A549, H460 and H1975) by inducing cell cycle arrest and senescence in a dose-dependent manner. In particular, YYJD induces significant G2/M phase arrest and inhibits the colony formation of lung cancer cells. Moreover, we found that administration of YYJD could inhibit the growth of xenografted lung cancer cells in nude mice without loss in body weight. Our findings suggest that the herbal formula YYJD is a potential anti-tumor agent against lung cancer.
Highlights
Lung cancer is one of the most commonly diagnosed malignant tumors and remains the major cause of cancer-related death in the world[1]
Cell cycle analysis revealed that the proportion of lung cancer cells in G2/M phase was significantly increased in a dose-dependent manner upon YYJD treatment for 24 h, while the proportion of lung cancer cells in G1 and S phases was decreased (Fig. 1B)
We found that IL-6 and IL-8 proteins and their mRNA levels were significantly increased in A549 cells after treatment with YYJD (Fig. 3B,C)
Summary
Lung cancer is one of the most commonly diagnosed malignant tumors and remains the major cause of cancer-related death in the world[1]. Even though new treatment approaches are emerging, the 5-year survival rate is less than 20%3. Jinfukang is a herb formula and has been clinically used to treat human lung cancer patients for many years. Previous studies have revealed that Jinfukang inhibits tumor growth in mice model of lung cancer, suppresses cellular proliferation and induces apoptosis of lung cancer cells[8,9,10]. We examined the mechanism of anti-tumor effect of YYJD and found that YYJD exerted anti-proliferation and pro-senescence effects in lung cancer cells. It suppressed growth of lung cancer-xenograft in nude mice
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