Abstract
Sequential hepatic changes induced by dimethylnitrosamine in normal-fed and protein-depleted rats were studied at various times between 1 day and 4 weeks. In the early stages a centrilobular zone of hemorrhagic necrosis was seen involving both hepatic parenchymal cells and sinusoid lining cells. This zone was replaced by granulation tissue which was compressed around patent central veins by the regenerating hepatic tissue. Most central veins remained patent throughout but became cuffed by scar tissue. In the areas of scarring the central veins were dilated and tortous but serial sections failed to demonstrate occluded central veins. The only occluded vessel seen was a thrombosed collecting vein. It is suggested that the raised portal pressure may be a result of the extramural fibrosis as no significant “veno-occlusion” is seen.
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