Abstract
Hepatotoxicity resulting from po administration of a single dose of CCNU to dogs was studied by weekly determinations of liver function tests and performance of percutaneous liver biopsies. Histochemical stains for glycogen and alkaline phosphatase in liver sections revealed an effect on these parameters within 1–2 weeks after dosage, the earliest sign of drug toxicity. Histopathologic changes were evident 7–14 days later, when increased activity of serum alanine aminotransferase was also present. Chemical indices of liver abnormalities were reversible, whereas glycogen depletion and increased alkaline phosphatase activity in liver biopsies persisted throughout the 2- to 3-month observation period. This study demonstrates the feasibility and usefulness of serial percutaneous liver biopsies in determining both the qualitative and quantitative features of developing and recovering from drug toxicity in the dog.
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