Abstract
In the dimethylnitrosamine (DMN)-induced hepatic fibrosis Wistar rat model, the mycelium extract of Phellinus linteus (PLE) (20 mg/Kg) displayed significant protection against hepatic fibrosis. The present investigation characterized eleven new ionone derivatives, phellinulins D–N (4–14), from the P. linteus mycelium extract and the relative stereochemical structures were constructed according to the spectroscopic and spectrometric analytical results. Some purified compounds were examined for their inhibitory effects on activated rat hepatic stellate cells (HSCs) and several isolates did exhibit significant protection. The results indicated that the mycelium of P. linteus could be explored as a hepatoprotective drug or healthy food candidate in the near future.
Highlights
Medicinal fungi could produce various bioactive metabolites including antibiotics [1], anti-cancer drugs [2,3] and immunosuppressants [4,5]
Both the positive control exposed to silymarin and Phellinus linteus (PLE) treatment could effectively attenuate the liver cell damage, fibrosis and collage accumulation induced by DMN application
These findings suggest that PLE could significantly prevent the hepatic detriment and fibrogenesis caused by chemical toxicity such as DMN
Summary
Medicinal fungi could produce various bioactive metabolites including antibiotics [1], anti-cancer drugs [2,3] and immunosuppressants [4,5]. Recent research results indicated that Sangwhang (Phellinus linteus) displayed the hepatoprotective and antihepatotoxic effects [6,7,8,9,10]. P. linteus (Hymenochaetaceae) was commonly used as medicines or healthy foods in oriental countries to treat several healthy problems such as ulcer, diabetes, cancer and infections. P. linteus exhibited wide spectrum of bioactivities, such as anti-platelet aggregation, anti-diabetic, anti-dementia, antioxidant, anti-inflammatory, cytotoxic and anti-viral effects [13,14,15,16,17,18].
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