Hepatoprotective Effects of Sukari Dates Extract (Phoenix dactylifera L.) Against ALT (Alanine aminotransferase) and AST (Aspartate aminotransferase) Profile in Male Wistar Rats After Induced by Meloxicam

Abstract

Meloxicam is a non-steroidal anti-inflammatory drug (NSAID) that is frequently administered to animals as an analgesic, antipyretic, and anti-inflammatory medication. Meloxicam overdose and liver damage can occur if taken for an extended period of time without first consulting a veterinarian. Sukari dates extract can neutralize the effects of free radicals and protect the liver when taken orally. After being induced by a toxic dose of meloxicam, the purpose of this study is to demonstrate that the administration of sukari dates extract may reduce the profile of ALT and AST. 24 male wistar rats were used in this laboratory experiment, which was divided into four groups (n=6). Positive control group (K2) received 30 mg/kg BW meloxicam and 1% Na CMC, while treatment group 1 (P1) received 500 mg/kg BW sukari dates extract and 30 mg/kg BW meloxicam. Treatment group 2 (P2) received 1000 mg/kg BW sukari dates extract and 30 mg/kg BW meloxicam. The negative control group (K1) received 1% Na CMC. The study lasted for 12 days, and on the 12th day, blood samples were taken for analysis. The ALT profile decreased to 67.17 U/L and 63.00 U/L in P1 and P2, respectively, and the AST profile decreased to 142.83 U/L and 125.83 U/L. As a result, it can be concluded that toxic doses of meloxicam can cause sukari dates extract to reduce ALT and AST profiles.