Abstract
Helicteres hirsuta Lour. is a traditional Vietnamese medicine for treating chronic liver diseases such as cirrhosis and liver cancer. Many in vitro and in vivo experiments have demonstrated that the extracts and isolated compounds from H. hirsuta have diverse pharmacological activities, including antioxidant, anti-inflammatory, and anti-cancer effects. However, the hepatoprotective effects have not been reported until now. Therefore, the methanolic and ethanolic extracts of the aerial part of the H. hirsuta L. (HHM and HHE-1/1) were examined on liver fibrosis induced by carbon tetrachloride (CCl4) in rats for the first time. The results revealed that all the livers of the model group had stage F4 cirrhosis; the group that received silymarin, and HHM and HHE-1/1 had milder liver damage cirrhosis stage F1-F2 which implies that the methanolic and ethanolic extracts of H. hirsute have a definite advantage in the development of food or oral medications for hepatoprotective activity.
Highlights
Cirrhosis is the last stage of chronic liver disease
The results demonstrated that the MeOH extract of H. hirsuta contained many bioactive compounds, including alkaloids, steroids, lignans, and phenolics
Our results demonstrate the protective effect of silymarin and H. hirsuta extracts when administered to rats, which can be used as a functional food to protect the liver function
Summary
Cirrhosis is the last stage of chronic liver disease. Cirrhosis prevention and treatment is a problem of medicine. Many traditional medicine remedies have proven effective in the prevention and treatment of cirrhosis [1]. According to traditional Vietnamese medicine, H. hirsuta is used to manage various ailments such as boils, pain relief, detoxification, dysentery, flu, smallpox, measles, malaria, snakebites, and especially liver diseases [3] such as cirrhosis, and liver cancer. Some studies show that H. hirsuta extract has diverse pharmacological effects, including antioxidant, anti-inflammatory, and anti-cancer in vitro [4,5,6]. At present, the pharmacological effects of the treatment of liver diseases of this plant have not been studied
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