Abstract
Lactic acid‐fermented garlic extract (LAFGE) has been shown to have hepatoprotective role in liver diseases. This study was conducted to evaluate the efficacy of a new LAFGE‐based hepatoprotective functional food product (named D‐18‐007) formulated with other additive components, including l‐arginine, l‐ornithine, and the leaf extract of licorice and artichoke. In a rat model of d‐galactosamine(GalN)/LPS‐induced liver injury, the survival was significantly higher in animals treated with D‐18‐007 than in animals treated with LAFGE. The hepatic injury was alleviated by either LAFGE or D‐18‐007, but the overall effect was more significant in D‐18‐007, as shown by the necrosis, histology, and serum analyses. Also, the decrease in GalN/LPS‐induced lipid peroxidation in the liver tissue was more significant in D‐18‐007 than LAFGE. The decrease in IL‐6 protein in the liver was similar between LAFGE and D‐18‐007. Moreover, we compared the amount of the bile in normal animals and found that D‐18‐007 has better choleretic activity than LAFGE. Using this acute liver injury model, our results suggest that D‐18‐007 has an enhanced hepatoprotective effect in acute liver injury compared with LAFGE alone.
Highlights
Using this acute liver injury model, our results suggest that D-18-007 has an enhanced hepatoprotective effect in acute liver injury compared with Lactic acid-fermented garlic extract (LAFGE) alone
We have recently developed an advanced hepatoprotective food product named D-18-007, a LAFGE (Choi et al, 2014)-based product that had been reformulated to contain the extracts of artichoke and licorice as well as l-arginine and l-ornithine
We evaluated whether D-18-007 had a greater effect on the rate of bile production compared with LAFGE, since D-18-007 contains artichoke, which is known to increase bile secretion
Summary
The hepatoprotective effect of LAFGE has been well-reported in several liver disease models (Guan et al, 2018; Lee et al, 2016; Shin et al, 2014). We evaluated whether D-18-007 has an enhanced hepatoprotective effect over LAFGE alone in a rat model of acute liver injury induced by d-GalN/LPS. We analyzed the serum levels of ALT and AST and found that GalN/LPS-induced damage to the liver in vehicle-treated rats.
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