Abstract
BackgroundHepatoid adenocarcinoma (HAC) is a peculiar type of extrahepatic adenocarcinoma generally characterized by adenocarcinomatous and hepatocellular carcinoma (HCC)-like foci. Stomach is the most frequent site where hepatoid adenocarcinoma occurs, although it has been described in many other organs. On the other side, liposarcoma is a rare, malignant tumor that develops from fat cells.Case presentationWe describe here a case of hepatoid carcinoma in collision with a liposarcoma of the left colon serosa in a 71-year-old man. It presented as an abdominal mass involving several organs, falsely mimicking metastatic colonic adenocarcinoma. Recognition of this entity was evident on microscopic evaluation following surgery. The patient had an objective response following liposomal antracycline chemotherapy, with a 3-year overall survival.ConclusionTo our knowledge, this is the first case of a hepatoid tumor colliding with a liposarcoma of the left colon serosa reported to date.
Highlights
Hepatoid adenocarcinoma (HAC) is a peculiar type of extrahepatic adenocarcinoma generally characterized by adenocarcinomatous and hepatocellular carcinoma (HCC)-like foci
Hepatoid carcinoma has been found in the stomach [1,2], but it occurs in many other organs
This paper describes the unusual occurrence of a hepatoid carcinoma colliding with a liposarcoma
Summary
Hepatoid adenocarcinoma (HAC) is a type of extrahepatic adenocarcinoma, which shows a striking morphologic similarity to hepatocellular carcinoma. His past medical history was significant for a monoclonal gammopathy and surgery for hip prosthesis 2 years before the current admission At another hospital an abdominal computed tomography (CT) scan had revealed a left-sided mass (10 × 9 cm) involving the diaphragm, spleen, and, from the outside, the left colon flexure. Cells in the nodules had polygonal appearance, acidophilic cytoplasm, and large, single or multiple hyperchromatic nuclei, often with vacuolization. These cells stained positive for AFP on immunohistochemistry (Figure 3). Http://www.wjso.com/content/5/1/42 of this case was the unusual presentation of the hepatoid carcinoma, which showed itself as an abdominal extracolonic mass, whereas in other reported cases it would arise in such definite organs as the ovary, the lung or the bladder
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