Abstract
To study the possibility that liver metabolism of acrylonitrile (ACN) could produce a stable carcinogenic metabolite that causes the brain tumors produced by ACN, the ability of hepatocytes to generate a stable transportable mutagenic metabolite in culture was studied. ACN did not produce sister chromatid exchanges (SCEs) in Chinese hamster ovary (CHO) cells, but a significant increase was produced when CHO cells were co-cultured with freshly isolated rat hepatocytes. Induction of SCE in CHO cells co-cultured with hepatocytes suggests that the liver cells metabolize ACN and the reactive metabolite is transported from them to the CHO cells.
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