Abstract
Hepatocyte growth factor (HGF) is a crucial factor associated with development, progression and metastasis of colorectal cancer (CRC). However, its prognostic value remains unclear. Thus studies referring to the correlation between HGF and CRC patients’ prognosis were included to explore the role of HGF in CRC. At last nine articles were included. The results showed that the over-expression of HGF was associated with a poor prognosis, presented through overall survival (OS, Hazard ratio (HR) = 2.50, 95% confidence interval (CI): 2.12–2.96) and disease-free survival (DFS, HR = 1.99, 95% CI: 1.59–2.50). Subgroup analysis indicated that no significant difference was found between the Asian countries (OS: HR = 2.37; DFS: HR = 2.02) and the non-Asian countries (OS: HR = 3.15; DFS: HR = 1.87), between the studies that used univariate analyses (OS: HR = 2.51; DFS: HR = 2.07) and those that used multivariate analyses (OS: HR = 2.65; DFS: HR = 1.78), and between metastatic CRC (OS: HR = 2.26; DFS: HR = 2.06) and stage I-IV CRC (OS: HR = 3.08; DFS: HR = 0.70). Our meta-analysis has shown that the over-expression of HGF is valuable in CRC prognosis evaluation. This conclusion should be further confirmed by large-sample cohort studies.
Highlights
Colorectal cancer (CRC, including colon cancer and rectal cancer) is the third most commonly diagnosed cancer in males and the second in females, with an estimated 1.4 million cases and 693,900 deaths in 2012
The results showed that the over-expression of Hepatocyte growth factor (HGF) was associated with a poor prognosis, presented through overall survival (OS, Hazard ratio (HR) = 2.50, 95% confidence interval (CI): 2.12–2.96) and disease-free survival (DFS, hazard ratio (HR) = 1.99, 95% CI: 1.59–2.50)
HGF exerts its biological effects via its tyrosine kinase cell surface receptor, hepatocyte growth factor receptor (HGFR), which is known as mesenchymal to epithelial transition factor (MET) [6, 7]
Summary
Colorectal cancer (CRC, including colon cancer and rectal cancer) is the third most commonly diagnosed cancer in males and the second in females, with an estimated 1.4 million cases and 693,900 deaths in 2012. Almost 694,000 deaths from CRC are estimated to have occurred in 2012, and these accounted for approximately 8.5% of all cancer deaths [3]. HGF exerts its biological effects via its tyrosine kinase cell surface receptor, hepatocyte growth factor receptor (HGFR), which is known as mesenchymal to epithelial transition factor (MET) [6, 7]. When it is aberrantly activated, the HGF-MET pathway is involved www.impactjournals.com/oncotarget in the regulation of proliferation, motility, invasion and metastasis via the phosphorylation and activation of downstream signaling pathways, which promote tumorigenesis [8]
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