Hepatocurative Properties of Eucalyptus camaldulensis Stem Bark Extract

Abstract

The research investigates the hepatocurative potentials of Eucalyptus camaldulensis solvents extract on CCl4 induced liver damage using albino rats, partial characterization of the most active extract was done using GCMS techniques. Forty-two rats were placed into seven groups of six rats each. Group I and II were normal control and test control respectively. Groups III to VII were induced with liver damage using 120mg/kg of CCl4 and administered with standard drug, n-hexane extract (E1), chloroform extract (E2), ethyl acetate extract (E) and methanol extract (E4) respectively. 24 hours after CCl4 administration, a significant (p<0.05) increase in mean serum level activities of AST, ALT, ALP with decrease in conjugated bilirubin and albumin concentration was recorded in test control group compared to normal control. This was reversed upon administration chloroform and methanol extract with former been most active. Antioxidant analysis reveals a significant (p<0.05) decrease in level of liver tissue antioxidant enzymes (SOD, CAT and GPx) with concomitant increase in MDA of test control compared to normal control rats. After extracts administration, increase in the antioxidants enzymes (SOD, Catalase and GPx) levels was recorded in methanol and standard drug administered groups.