Abstract
Hepatitis B virus infection is an uncommon cause of acute glomerulonephritis. We present a case of acute glomerulonephritis revealing a chronic viral hepatitis B. A 45 year-old man was admitted in the nephrology department of Hassan II university hospital (Fez, Morocco) for nephritic syndrome with advanced acute kidney injury. The investigations have revealed viral hepatitis B with a positive HBV-DNA and Others viral serology tests were negative. Renal biopsy showed a diffuse and global endocapillary proliferation without extra-capillary proliferation; and global deposits of C3 and Ig G On immunofluorescence. There wasn't any other infectious cause. We thus retained the diagnosis of hepatitis B virus-associated acute glomerulonephritis. He was given entecavir and corticosteroids. Three months later, the evolution was marked by the normalization of renal function, negativity of proteinuria and HBV DNA became undetectable. There was no relapse of glomerulonephritis and HBV viral load was still negative after one year follow-up.
Highlights
Hepatitis B virus (HBV) infection is an important health problem especially in developing countries
We report the case of a patient admitted in nephrology with acute glomerulonephritis revealing a chronic viral hepatitis B
A 45 years old male, he had uncomplicated type 2 diabetes for at least 7 years treated by insulin. He was admitted in June 2011 in the nephrology department of Hassan II university hospital (Fez, Morocco) for nephritic syndrome with advanced acute kidney injury
Summary
Hepatitis B virus (HBV) infection is an important health problem especially in developing countries. We report the case of a patient admitted in nephrology with acute glomerulonephritis revealing a chronic viral hepatitis B. A 45 years old male, he had uncomplicated type 2 diabetes for at least 7 years treated by insulin He was admitted in June 2011 in the nephrology department of Hassan II university hospital (Fez, Morocco) for nephritic syndrome with advanced acute kidney injury. The clinical exam has showed a conscious patient , hypertensive at 220/120 mm Hg, the heart rate was at135b/mn, the FR=25c/mn. The patient has received a strong antiviral treatment by Entecavir 0.5 mg per week adapted to renal function. Evolution was marked by the improvement of renal function and negativity of viral load. There was no relapse of glomerulonephritis and HBV viral load was still negative after one year follow-up
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