Abstract
The threshold for the conversion of parenterally administered glucose to hepatic fat was estimated by measuring the amount of fat accumulated in the liver of malnourished cancer patients. Patients were given 7–10 days of TPN with glucose (47 kcal/kg/d) as the sole non-protein calorie source. The derived threshold, 42 kcal/kd/day) is in reasonable accord with the value for the glucose oxidation capacity derived from indirect methods. Most of the newly synthesized fat accumulates in the liver.
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