Abstract
The influence of dimethyl sulfoxide (DMSO) on the hemolytic activity of phenol has been investigated in vitro. Although DMSO freely penetrates the erythrocytic membrane and, in high concentrations, is destructive to red cells, it did not enhance but greatly reduced phenol-induced hemolysis of both washed and unwashed erythrocytes. This interference may be manifest through chemical interaction with phenol or through a direct cellular effect. The influence of dimethyl sulfoxide (DMSO) on the hemolytic activity of phenol has been investigated in vitro. Although DMSO freely penetrates the erythrocytic membrane and, in high concentrations, is destructive to red cells, it did not enhance but greatly reduced phenol-induced hemolysis of both washed and unwashed erythrocytes. This interference may be manifest through chemical interaction with phenol or through a direct cellular effect.
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