Hemoglobin, white blood cell, mean platelet volume, C reactive protein, and their association with overweight/obesity among adolescents: a multicenter cross-sectional study.

Usefulness of Mean Platelet Volume as a Biomarker for Long-Term Outcomes After Percutaneous Coronary Intervention

Mean Platelet Volume and Long-Term Mortality in Patients Undergoing Percutaneous Coronary Intervention

<b>Background:</b> Various thrombocyte markers and white blood cell levels and their subtypes have recently been investigated in association with inflammation. The purpose of this study was to determine the correlation of mean platelet volume (MPV) and neutrophil/lymphocyte ratio (NLR) with disease activation and clinical para­meters in rheumatoid arthritis (RA) patients. <b>Methods:</b> 84 RA patients and 60 healthy controls were included. Platelet, MPV, white cell, neutrophil and lymphocyte levels in full blood counts were investigated, and NLR was calculated. Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF), anti-cyclic citrullinated peptide (anti-CCP), disease activation score (DAS 28) and a health assessment questionnaire (HAQ) were used in the evaluation of RA. <b>Results:</b> In the present study a total of 144 patients was enrolled, 84 with RA and 60 healthy individuals. 75.2% (n=108) were women and 24.8% (n=36) were men. The patients with RA had lower MPV than control individuals (MPV; 8.52±1.15 fL and 8.92±0.87 fL, respectively) and CRP (r:−0.234, p=0.005). RA patients' mean NLR was significantly higher than that of the control group (2.74±1.74 and 1.80±0.78, respectively; p<0.001). Furthermore, anti-CCP positive patients had higher NLR than anti-CCP negative patients (NLR; 2.51±1.92 and 1.95±1.22, p=0.019 respectively). NLR was positively correlated with ESR (r=0.190, p=0.023), CRP (r=0.230, p=0.035) and anti-CCP (r=0.300, p=0.005). <b>Conclusion:</b> In conclusion, MPV and NLR together with acute phase reactants can be a useful index for showing inflammation in RA patients.

Clinical detection of inflammatory markers is useful to assess the degree of nocturnal hypoxia and predict the presence of complications in obstructive sleep apnea syndrome (OSAS) patients. Nowadays, some researchers proposed that hematological parameters could be substituted for novel disease-specific biochemical markers (such as C-reactive protein) because they were comparatively cheap, simple and practical. But there was a contradiction whether the hematological parameters were positively correlated with the OSAS severity. Medical databases were searched included PubMed, Web of Science, Scopus, Cochrane Library, Clinical Trial, Embase and Google Scholar (up to March 29, 2018). We used weighted mean differences (WMDs) with 95% confidence intervals (CIs) from random-effects model. Seventeen studies were included in this meta-analysis and results were presented by different hematological parameters. Pooled analysis showed that OSAS was associated with a high level of WBC (white blood cell, 11 studies, 2,206 subjects, WMD: 0.58; 95% CI: 0.31 to 0.85; P<0.0001), NLR (neutrophil-to-lymphocyte ratio, 5 studies, 1416 subjects, WMD: 0.46; 95% CI: 0.13 to 0.80; P=0.007), MPV (mean platelet volume, 8 studies, 1,854 subjects, WMD: 0.63; 95% CI: 0.29 to 0.98; P=0.0004), PDW (platelet distribution width, 6 studies, 1,911 subjects, WMD: 0.76; 95% CI: 0.47 to 1.06; P<0.00001), PLR (platelet-to-lymphocyte ratio, 3 studies, 998 subjects, WMD: 21.76; 95% CI: 8.54 to 34.99; P=0.001), RDW (red cell distribution width, 5 studies, 1,701 subjects, WMD: 0.31; 95% CI: 0.11 to 0.51; P=0.002) and HCT (hematocrit, 3 studies, 662 subjects, WMD: 1.58; 95% CI: 0.52 to 2.64; P=0.003). But OSAS was associated with a low level of LYM (lymphocyte, 5 studies, 1,285 subjects, WMD: -0.27; 95% CI: -0.49 to -0.06; P=0.01). There was a gradual rising trend from mild OSAS to severe OSAS existed in all subgroups. Hematological indices are comparatively Simple, Inexpensive and Practical Severity Markers of OSAS including WBC, LYM, NLR, MPV, PDW, PLR, RDW and HCT.

Multisystem inflammatory syndrome in children (MIS-C) is a novel pediatric disorder associated with coronavirus disease 2019. However, no laboratory parameters can diagnose MIS-C. This study aimed to determine the changes in mean platelet volume (MPV) and investigate its relationship with cardiac involvement in MIS-C. In this single-center retrospective study, 35 children with MIS-C, 35 healthy children and 35 febrile children were enrolled. Patients with MIS-C were further subdivided depending on the presence of cardiac involvement. For all patients, the white blood cell, absolute neutrophil, absolute lymphocyte, platelet counts, MPV and C-reactive protein levels were recorded. Ferritin, D-dimer, troponin and CK-MB levels and the day when IVIG was administered were recorded and compared between groups. Thirteen patients with MIS-C had cardiac involvement. The mean MPV of the MIS-C group was significantly higher than those of the healthy ( P = 0.0001) and febrile ( P = 0.027) groups. Using a cutoff of >7.6 fL, the MPV had a sensitivity of 82.86% and specificity of 82.75%, and the area under the MPV receiver operating characteristics curve was 0.896 (0.799-0.956). The MPV was significantly higher in patients with cardiac involvement than in those without ( P = 0.031). Logistic regression analysis revealed that the association between the MPV and cardiac involvement was significant (odds ratio, 2.28; 95% confidence interval, 1.04-2.95; P = 0 .039). The MPV may indicate cardiac involvement in patients with MIS-C. Large cohort studies are needed to define an accurate cutoff value for the MPV.

The aim of this study is to examine the associations between white blood cell (WBC), hemoglobin (Hb), neutrophil, lymphocyte, platelet, mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) levels in patients with recurrent aphthous stomatitis (RAS). For this study, 137 patients with RAS and 137 healthy controls were recruited. The study participants had no systemic diseases except RAS. Serum WBC, Hb, neutrophil, lymphocyte, platelet, MPV, PLR, NLR, ESR, and CRP levels were recorded in the active period for all patients with RAS and controls. There was no statistically significant difference in the WBC, Hb, neutrophil, lymphocyte, platelet, MPV, NLR PLR, ESR, and CRP levels between patients with RAS and controls. No differences were observed for WBC, Hb, neutrophil, lymphocyte, platelet, MPV, NLR, PLR, ESR, and CRP levels between patients with RAS and controls. These parameters therefore cannot be used as markers for inflammation or inflammation severity in patients with RAS.

Background: The measurements of platelet count, mean platelet volume (MPV), WBC are routinely available nowadays. The aim of this study was to determine age dependent aetiology and relationship of these parameters whether they were associated with the known markers of disease activity, erythrocyte sedimentation rate (ESR) and C- reactive protein (CRP) in Tuberculosis. Methods: This descriptive study was done on 500 patients with platelet count &gt; 450,000/ μl and the cause being reactive. Platelet count, WBC, MPV, ESR, and CRP were measured at the time of hospitalization. Result: Most common cause of reactive thrombocytosis was found to be infection (28.8%), tissue damage (16.4%), iron deficiency anemia (16.2%), malignancy (9.6%), inflammation (non-tuberculosis) (9.4%), diabetes mellitus (6.4%), tuberculosis (6.0%) respectively. There was low degree of positive correlation between reactive thrombocytosis with WBC (r = 0.337, P= 0.06) and ESR (r = .277, P= &gt;0.05). There was low degree of negative correlation between reactive thrombocytosis and CRP (r= -.131, P= &gt;0.05). There was significant negative correlation between reactive thrombocytosis and MPV (r = -.561, P= &gt;0.001). Conclusion: This study demonstrated a higher level of platelet count and lower MPV in all the patients having reactive thrombocytosis. The changes in these parameters (platelets count, WBC, MPV, CRP and ESR) may reflect a reaction to the inflammatory condition. Therefore, in endemic areas, the presence of such haematological peripheral blood changes may raise the suspicion of tuberculosis.

Background: The measurements of platelet count, mean platelet volume (MPV), WBC are routinely available nowadays. The aim of this study was to determine aetiology and relationship of these parameters whether they were associated with the known markers of disease activity, erythrocyte sedimentation rate (ESR) and C- reactive protein (CRP) in infections.&#x0D; Methods: This descriptive study was done on 500 patients with platelet count &gt; 450,000/ μl and the cause being reactive. Platelet count, WBC, MPV, ESR, and CRP were measured at the time of hospitalization.&#x0D; Result: Most common cause of reactive thrombocytosis was Infections (28.8%), Tissue damage (16.4%), Iron deficiency anemia (16.2%), Malignancy (9.6%) and Inflammation (9.4%). In infections, bacterial infections (88%) were found to be more common. There was low degree of positive correlation between reactive thrombocytosis and WBC (r = 0.124, P &gt;0.05) , ESR ( r = .147, P= 0.07) , MPV ( r = .077, P &gt;0.05) in infections. There was significant negative correlation between reactive thrombocytosis and CRP in infections (r = -.199, P= 0.017).&#x0D; Conclusion: This study demonstrated a higher level of platelet count and lower MPV in all the patients having reactive thrombocytosis irrespective of it’s etiology. There was low degree of positive correlation between platelet count and WBC, ESR and MPV in infections and a significant negative correlation with CRP. We propose that platelet parameters may be considered as reliable markers for assessment of disease activity.

To explore the application value of SAA (serum amyloid A), CRP (C reactive protein), PCT (procalcitonin), WBC (white blood cell) and N% (neutrophil %) in the diagnosis of neonatal septicemia. This study was a retrospective study. 173 children with clinically diagnosed septicemia and 66 children with definitely diagnosed septicemia admitted to the Department of Neonatology, the Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China,from January 2022 to January 2024 were selected as the case group, and 148 children with neonatal jaundice who were hospitalized during the same period were selected as the control group. Fasting venous blood was collected within 24 hours after the children's admission to detect the levels of serum WBC, N%, SAA, CRP and PCT. One-way analysis of variance and Kruskal-Wallis H test were used to compare the general data and inflammatory index levels of the three groups of children. The correlation analysis between SAA and other inflammatory indicators was conducted using Spearman correlation analysis. The receiver operating characteristic (ROC) curve was used to determine the diagnostic efficacy of different inflammatory indicators for patients with definitely diagnosed septicemia and those with clinically diagnosed septicemia, and for those with clinically diagnosed septicemia and those without infection. The results showed that the levels of WBC [(16.88±5.64)×109/L], N% [70.00 (63.00, 75.00)], PCT [2.22 (1.20, 5.55) mg/L], CRP [3.00 (0.50, 10.30) mg/L], SAA [19.70 (10.82, 49.90) mg/L] in the clinically diagnosed septicemia group and WBC [(16.10±7.48)×109/L], N% [73.50 (61.50, 80.93)], PCT [5.35 (0.69, 20.07) mg/L], CRP [15.52 (4.98, 30.50) mg/L], SAA [43.95 (14.00, 175.98) mg/L] in the definitely diagnosed septicemia group were all higher than those in the control group (11.17±3.38)×109/L, 49.81 (36.93, 62.75), 0.20 (0.07, 0.99) mg/L, 0.54 (0.20, 1.40) mg/L, 5.15 (3.60, 8.68) mg/L, and the differences were all statistically significant (all P<0.05). Spearman correlation analysis showed that the level of SAA was positively correlated with WBC, N%, PCT and CRP (rs=0.453, 0.540, 0.343, 0.550, all P<0.05). ROC curve analysis showed that the area under ROC curve(AUC) of SAA for the definitely diagnosed septicemia group and the clinically diagnosed septicemia group was higher than that of other inflammatory indicators, among them, the AUC of SAA for diagnosing the definitely diagnosed neonatal septicemia group was 0.933 (95%CI: 0.809-1.000, P<0.05), with a sensitivity of 92.90% and a specificity of 99.30%. The AUC of SAA for diagnosing the clinically diagnosed septicemia group was 0.861 (95%CI: 0.818-0.904, P<0.05), with a sensitivity of 83.20% and a specificity of 81.80%. In conclusion, compared with CRP, PCT, WBC and N%, SAA has higher sensitivity and specificity for distinguishing neonatal septicemia (including definitely diagnosed septicemia and clinically diagnosed septicemia), and has certain auxiliary diagnostic value for neonatal septicemia.

Background and Aims Higher Mean Platelet Volume (MPV), as an indicator of larger and hyper-reactive platelets and low serum Mg levels (sMg) have emerged as cardiovascular risk markers, in the general and dialysis population. Magnesium deficiency is linked to platelet hyper-reactivity. Since HypoMagnesemia is common and associated to increased mortality among Peritoneal Dialysis (PD) patients, we aimed to investigate the association of sMg with MVP in PD patients. Method We studied 95 stable PD patients, 51 men 44 women, with a mean age of 63 ±14 years. Data analyzed included patients demographics, clinical and biochemical data. Univariate and multivariate regression analysis were used to test the associations of variables related to MPV. Results: . The mean platelet (PLT) volume was 9.4 ±1.5 (median: 9.2) fl. The mean platelet (PLT) count was 235 ± 69 (median: 233) [x103μ/L]. The mean sMg was 2.25 ± 0.47 (median: 2.2) mg/dl. MPV was associated positively (p=0.303; p&amp;lt;0.01) with C-reactive protein (CRP) and negatively with sMg (r= -0.246; p&amp;lt;0.05), use of Renin Angiotensin System (RAS) Inhibitors (r=-0.273; p&amp;lt;0.05), PLT count (r=-0.360; p&amp;lt;0.001) and white blood cell (WBC) count (r=-0.254; p&amp;lt;0.05). The results of our multiple regression model (Table) showed that all the above mentioned factors that were included in the model, except WBC, were independent determinants of MPV. Conclusion Our results show a significant inverse correlation of serum Magnesium with Mean Platelet Volume in Peritoneal Dialysis patients. Given the emerging role of Mg in platelet reactivity, sustaining higher sMg levels, along with minimizing inflammation and using RAS inhibitors may improve cardiovascular outcomes in PD patients via modulation of MPV.

Background:Inflammatory processes play a central role in rheumatoid arthritis (RA), involving complex interactions among cytokines and blood cell components. Current clinical tools, including the Disease Activity Score (DAS28), and biomarkers such as erythrocyte sedimentation rate and C-reactive protein (CRP), have limitations in monitoring disease activity.Objectives:This study aimed to assess the utility of routine hematological parameters as potential biomarkers for diagnosing RA and evaluating disease activity in drug-naïve patients.Methods:In this single-center retrospective study, 486 RA patients and 301 age- and sex-matched healthy controls were analyzed. Drug-naïve RA patients (not treated with disease-modifying antirheumatic drugs or glucocorticoids) were selected according to the 2010 American College of Rheumatology/European League Against Rheumatism criteria. Hematological parameters (white blood cell count and differential, hemoglobin (HGB), platelet count (PLT), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), red cell distribution width (RDW), and mean platelet volume (MPV)) were obtained and calculated from complete blood counts. Disease activity was assessed using the 28-joint DAS28 with CRP. Diagnostic accuracy and association with disease activity were evaluated using receiver operating characteristic (ROC) analysis, correlation tests, and logistic regression.Results:Compared with controls, RA patients exhibited distinct hematological profiles, with significantly higher NLR, PLR, and RDW, and lower MPV (all p < 0.001). Multivariate logistic regression identified MPV (odds ratio (OR): 1.315, 95% confidence interval (CI): 1.085–1.594, p = 0.005) and age (OR: 0.984, 95% CI: 0.969–0.999, p = 0.038) as independent factors associated with moderate-to-high disease activity. MPV showed significant inverse correlations with DAS28-CRP (r = −0.098, p = 0.031) and CRP (r = −0.148, p = 0.001). ROC analysis demonstrated that NLR had a modest performance (area under the curve (AUC): 0.676) for distinguishing RA patients from controls, and its performance in differentiating disease activity levels was weak (AUC: 0.598).Conclusion:This study suggests that hematological indices, particularly NLR, PLR, and MPV, hold potential as supplementary biomarkers in RA, but not standalone diagnostic tools. MPV emerged as an independent marker associated with higher disease activity, yet its clinical significance requires further validation. These readily available parameters may be integrated as complementary components of a broader diagnostic and monitoring strategy.

Introduction: To determine the changes in mean platelet volume (MPV) and the neutrophil/lymphocyte ratio (NLR) in activation period among patients with ulcerative colitis (UC). Methods: Overall, 83 patients (49 female and 34 male) diagnosed with UC were retrospectively screened and includ- ed in this study. The complete blood count results, including hemoglobin, white blood cell (WBC) count, NLR, platelet count, and MPV, of all patients were recorded in both activation and remission periods. The serum C-reactive protein (CRP) and sedimentation levels of all patients were also recorded. Endoscopic disease activities (endoscopic activity index (EAI)) were also noted. Results: Compared with the remission periods, MPV values were statistically significantly lower (p=0.023) and NLR values were statistically significantly higher (p=0.011) in activation periods. In the correlation analysis, MPV levels were correlated with disease age (p=0.019), hemoglobin (p=0.012), WBC count (p=0.009), platelet count (p=0.001), sedimentation rate (p=0.001), CRP levels (p=0.009), and EAI (p=0.008) during activation periods. Conversely, the NLR did not correlate with MPV, hemoglobin, WBC, platelet count, or sedimentation and CRP levels; however, the NLR was also correlated with EAI (p=0.036). Discussion and Conclusion: We have studied two inexpensive, easily applicable, and noninvasive serum biomarkers, MPV and NLR, to determine UC activation and found that these two parameters are well correlated with other inflam- matory markers and EAI.

In this study, we aimed to determine the value of mean platelet (PLT) volume (MPV), PLTand PLT distribution width (PDW) levels as a marker in the prediction of mucosal healing (MH), steroid resistance (SR) and steroid dependence (SD) in newly diagnosed moderate and severely active patients with ulcerative colitis (UC), who did not receive medical treatment before. Two hundred forty-nine patients with severely or moderately active UC and 50 healthy subjects were enrolled in the study after retrospective analysis. Disease severity and MH of UC were determined according to the Mayo Score.According to the results of remission induction therapy, the patients were divided into two groups: Group 1; MH positive and Group 2; MH negative. UC patients with clinical remission (CR) but without MH were divided into two subgroups SD and non-SD during their follow-up. These two groups and subgroups were compared for variables. 42.6% of patients with UC had severe disease activation. 44.6% of patients with UC had pancolitis. After remission induction therapy, CR was observed in 84.3% of patients with UC. MH rate was 53.0%. SR rate was 15.7% and the SD rate was 16.1%. A strong positive correlation was observed between C reactive protein (CRP), PLTand Mayo score in the activation period (r=0.835 and p<0.001; r=0.883 and p<0.001; respectively). A strong negative correlation was observed between mean PLT volume (MPV), PDWlevels and Mayo score (r=-0.905 and p<0.001; r=-0.805 and p<0.001; respectively). According to the receiver operating characteristic curve (ROC) analysis, PLT had a sensitivity of 42.4% and a specificity of 22.7% in the prediction of MH at a cut-off value of 266.5x103/µL. MPV had a sensitivity of 83.5% and a specificity of 73.5% in the prediction of MH at a cut-off value of 8.05 fL. PDW had a sensitivity of 88.6% and a specificity of 84.5% in the prediction of MH at a cut-off value of 2.95 fL. PLT was determined with 92.5% sensitivity and 86.8% specificity in the prediction of SD at a cut-off value of 287.0x103/µL. MPV had a sensitivity of 86.8% and a specificity of 67.5% in the prediction of SD at a cut-off value of 7.95 fL. PDW had a sensitivity of 73.7% and a specificity of 72.5% in the prediction of SD at a cut-off value of 12.55 fL. There was a positive correlation between PLT levels and Mayo score, and a negative correlation between Mayo score and MPV or PDW levels. We think that PLT, MPV and PDW levels may be promising markers in the evaluation of disease activation/remission and severity. We believe that PLT, MPV and PDW levels will be determinative especially in the exclusion of SD, for UC patients with CR but without MH.

Erkan Cure, M.D., Mehmet Sabri Balik, M.D., Medine Cumhur Cure, M.D., Yilmaz Guvercin, M.D., Adem Erkut, M.D., Suleyman Yuce, M.D., and Davut Keskin, M.D.. Ann Lab Med 2013;33:367-70. https://doi.org/10.3343/alm.2013.33.5.367

Parameters derived from complete blood count, such as mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), have recently been proposed as measures of inflammation in addition to C-reactive protein (CRP), a classical inflammatory marker. Significant association of these parameters with atherosclerosis and complications have increasingly been reported. The aim of the study is to evaluate the relationship between these parameters and the presence of myocardial viability assessed with positron emission tomography (PET) in patients with ischaemic cardiomyopathy (ICM). A total of 122 ICM patients who had undergone PET were enrolled in this study. The patients were dichotomised depending on the presence of transmural scar. Group 1 consisted of 21 patients who had transmural scar tissue only, who were accepted as the group having non-viable myocardium. Group 2 consisted of 101 patients who had hibernation and/or non-transmural scar, who were accepted as the group having viable myocardium. Haematological parameters within 30 days of PET imaging were retrospectively analysed. There were no significant differences between the two groups regarding values of white blood cell, neutrophil, lymphocyte, platelet, haemoglobin, red cell distribution width, CRP, PLR, and NLR. Patients with non-viable myocardium have significantly higher levels of MPV (p = 0.002). In multiple logistic regression analysis, MPV (odds ratio [OR] = 0.373, 95% confidence interval [CI] 0.20-0.69, p = 0.002), was identified as an independent predictor of non-viable myocardium. In receiver-operator characteristic (ROC) analysis, a cut-point of 8.19 identified patients with non-viable myocardium (area under curve: 0.72, 95% CI 0.60-0.84). An MPV value greater than 8.19 demonstrated a sensitivity of 76% and a specificity of 55%. \ CONCLUSIONS: The present study showed that MPV is an inexpensive, clinical, and routinely measurable parameter that is associated with the presence of viable myocardium in ICM.