Abstract
Effects of sodium nitrite on the blood flow rate (V) in microvessels of rat cerebral cortex (5–15 µm in diameter), arterial pressure (AP), plasma osmotic pressure (Posm), and hematological parameters were studied. The mean V and AP in 15 min after administration of NaNO2 (3 mg/100 g mass) decrease by 36% and 45%, while in 30 and 45 min they increase by 14% and 7% and by 20% and 19% as compared with minimal values, respectively. At the end of the experiment, on the background of an elevation of Posm (3%), a decrease of total hemoglobin concentration and of the number of erythrocytes was accompanied by a decrease of the discocyte number from 81 to 35% and a reduction of cell diameters by 7%. It is concluded that NaNO2 produces block of local active mechanisms of the cerebral blood flow regulation. Compensatory responses in this case are provided by passive mechanisms (rheological blood properties) and systemic reactions.
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