Abstract
Objective To observe the hemocompatibility of a small-caliber expanded polytetrafluoroethylene vessel plate with heparin-collagen layer-by-layer assembly.Methods The study included the composite expanded polytetrafluoroethylene vessel plate group and the control expanded polytetrafluoroethylene vessel plate group.The composite small-caliber blood vessel plate was prepared by heparin-collagen layer-by-layer static electrical assemble onto expanded polytetrafluoroethylene.According to European Standard of ISO10993-4 and Chinese Standard of GB/T 16886,blood platelet adhesion test,hemolysis test and plasma recalcification time were applied.Results Scanning electronic microscopy revealed obvious platelet adhesion on the control expanded polytetrafluoroethylene vessel plate,while less occurred on the experimental group ( 2.5 ± 2.4 vs 28.5 ± 4.8,P ＜ 0.05 ).There was no significant hemolysis rate between the two groups (0.63％ vs 1.27％,P ＞0.05).The fibrin was not seen as long as 30 minutes in experimental group,significantly longer than that of the control group (8.5 minutes).Conclusion The composite small-caliber expanded polytetrafluoroethylene vessel plate has excellent antithrombotic acitivity and blood hemocompatibility. Key words: Expanded polytetrafluoroethylene; Artificial blood vessel plate; Small-caliber; Hemocompatibility
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