Hematological biochemical and liver function changes associated with BTEX exposure in a six year retrospective cohort study

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This 6-year retrospective cohort study aimed to investigate the health effects of exposure to BTEX compounds in a petroleum products distribution company in Iran. Blood samples were collected annually from both exposed and control groups at the start of each work shift and analyzed for a range of hematological, biochemical, and liver function parameters, including lymphocyte, neutrophil, ALT, AST, Hb, HCT, MCV, MCHC, platelet, WBC, RBC, TG, LDL, and HDL. Annual monitoring of BTEX exposure was conducted using the standard NIOSH 1501 method. The study found significant time-dependent effects of BTEX exposure on liver function, lipid profile, and hematopoietic parameters. Linear mixed-effects models revealed consistent increases in ALT, TG, Hb, and MCHC levels in the exposed group compared to the control group, with statistically significant differences (β = 1.10, p = 0.029; β = 6.56, p = 0.016; β = 0.85, p = 0.013; β = 0.87, p = 0.027). Additionally, the model fitting results for LDL indicated a decreasing trend in the exposed group compared to the control group, which was also statistically significant (β = -1.76, p = 0.034). These findings suggest that long-term exposure to BTEX compounds may have adverse health effects on the liver, lipid profile, and hematopoietic system. Further research with larger sample sizes and longer follow-up periods is needed to confirm these findings and explore the long-term health effects of BTEX exposure.