Hematologic and serum chemistry values following phencyclidine administration to Macaca mulatta

Abstract

Although phencyclidine is commonly used for restraint during blood sampling of laboratory primates, relatively little is known of its potential effects on clinical laboratory values examined during drug safety studies. Studies were consequently undertaken to determine the potential response of standard hematologic or blood chemistry parameters of Macaca mulatta to single or repeated doses of phencyclidine. Blood values of control and phencyclidine monkeys were determined at Weeks −5 and −1 prior to the treatment period and immediately prior to and at 1 and 24 hr after injection of saline or phenycyclidine during study Weeks 1, 3, and 5. At each sampling period, serum glucose concentrations of phencyclidine-treated monkeys declined sharply 1 hr after drug administration but returned to values near the control level by 24 hr. Other hematologic and serum chemistry values tested were not affected by phencyclidine administration. Thus, phencyclidine acutely altered glucose concentrations of laboratory primates but did not affect other laboratory values commonly determined in drug safety studies.