Abstract
Aim: To study the association of Helicobacter pylori infection with chronic antral gastritis in peptic ulcer disease patients and healthy population of Kashmir. Methods: 50 peptic ulcer patients (duodenal ulcer = 46, gastric ulcer = 2 and combined duodenal and gastric ulcer = 2) and 30 asymptomatic healthy volunteers were included in this study. Peptic ulcer was diagnosed on endoscopic examination. 4–6 punch biopsies were taken from gastric antrum in all the individuals and in case of gastric ulcer an additional biopsy was taken from the edge of the ulcer to exclude its malignant nature. Helicobacter pylori (H. pylori) organism was diagnosed using three different test methods, viz. Histology (using Giemsa Stain), Microbiology (Gram Stain) and Biochemistry (using one minute Endoscopy Room Test). Histological diagnosis of H. pylori was taken as the “gold standard” for the presence of H. pylori organism. Histological diagnosis of gastritis was made using Hematoxylin and Eosin Stain and the gastritis was classified as active chronic gastritis and superficial chronic gastritis. Results: Out of 30 peptic ulcer disease patients with associated antral gastritis, 27 (90%) were positive for H. pylori on histological examination (13 superficial chronic gastritis and 14 active chronic gastritis) whereas out of 8 healthy volunteers with histological evidence of chronic antral gastritis, H. pylori was observed in 7 individuals (87.50%) (4 active chronic gastritis and 3 superficial chronic gastritis). Conclusion: A highly significant association between H. pylori infection with chronic antral gastritis both in peptic ulcer disease patients and healthy volunteers of Kashmir was found in this study. Association between H. pylori infection and chronic gastritis was 90% in peptic ulcer group and 87.50% in healthy population (P<0.005).
Highlights
Peptic ulcer disease (PUD) and chronic gastritis are most common disorders throughout the whole world
This study consisted of 50 PUD patients (DU-46, GU-2 and combined duodenal ulcer (DU) and GU-2) whose disease was diagnosed on endoscopic examination and 30 asymptomatic healthy volunteers
The study was explained to the eligible individuals and informed written consent was obtained from each participant
Summary
Peptic ulcer disease (PUD) and chronic gastritis are most common disorders throughout the whole world. Chronic antral gastritis is a common finding in PUD especially in duodenal ulcer (DU)., Chronic antral gastritis occurs in gastric ulcers. One study has reported association between chronic gastritis and active duodenal ulcer as 100% compared to 50% in non-ulcer controls [1]. Since the isolation of small ’S’ shaped, gramnegative, catalase and oxidase positive microaerophilic multiflagellate H. pylori from gastric antrum by Marshall et al [2], a close relationship between chronic gastritis and H. pylori infection has been reported throughout the whole world. Helicobacter pylori infection has been strongly found to be associated with type B (chronic non-autoimmune) gastritis [2,3,4]
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