Abstract
BY electrophoretic analysis we have found large quantities of an exceptionally basic protein in the urine of five out of seven consecutive cases of chronic myelocytic leukaemia. In four cases the specific proteinuria occurred when induction of remission was achieved after X-irradiation directed against the enlarged spleen. In one case the protein was found before X-ray therapy, but irradiation evoked an increasing protein response. The proteins have been isolated and characterized as relatively low molecular weight constituents with the enzymatic properties of lysozyme.
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