Abstract
To study anti-tumor immunity mechanism induced by a reconstructed peptide complex-heat shock protein 70 (HSP70) and alphafetop-rotein (AFP), Mic e were immunized with AFP peptide, HSP70 and HSP70-AFP peptide complex es respectively. The killing effects of IFN-γ, TNF-α, perforin, granzyme B and CD8+ T cells on H22 cells were detected in each group of CD8+ T cell culture supernatants and investigate theimmune effect of heat shock protein 70 (HSP70)-alpha-fetoprotein (AFP)epitope peptide complex on mouse H22 hepatoma cells.
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