Abstract
BackgroundThere are few researches on hematological parameters (hemoglobin, red cell distribution width [RDW], white blood cells [WBCs], mean platelets volume [MPV], and heart rate variability [HRV]). There are no published data on this concept (HRV and hematological parameters) during pregnancy.MethodsA cross‐sectional study was conducted at Saad Abul Ela hospital in Khartoum, Sudan during the period of July to August 2018. Pregnant women with singleton, a live baby, were enrolled in this study. Clinical history and examination were performed. HRV (autonomic modulation) was assessed using time and frequency domain HRV indices.ResultsOne hundred and five pregnant women were enrolled. The median (quartile) of the age, parity, and gestational age was 30.0 (25.0‐35.0) years, 1.0 (0‐3.0), and 38.0 (32.0‐39.0) weeks, respectively. While there were positive correlations between hemoglobin and low frequency (LF), RDW and high frequency (HF), WBCs and HF Norm, WBCs and LF/HF, MPV and HF Norm, LF Norm and LF/HF, there was no significant correlation between the hematological (hemoglobin, WBCs, RDW, and MPV) and HRV parameters. Linear regression analysis showed no significant association between age, parity, gestational age, body mass index, hemoglobin, RDW, and HRV variables. The Log10 WBCs were negatively associated with Log10 HF (ms2/Hz). MPV was positively associated with LF Norm and negatively associated with HF Norm.ConclusionThe study failed to show significant associations between age, parity, gestational age, hemoglobin, RDW, and HRV variables. The WBCs were negatively associated with HF. MPV was positively associated with LF Norm, and it was negatively associated with HF Norm.
Highlights
Heart rate variability (HRV) is an informative tool in assessing cardiac autonomic modulations; it has a prognostic value in cardiac diseases, and it is widely used to assess the impact of autonomic imbalance on various diseases such as type 2 diabetes mellitus and obesity,[1,2] coronary heart disease, 3 and inflammatory conditions.[4]
While there were positive correlations between hemoglobin and low frequency (LF), red cell distribution width (RDW) and high frequency (HF), white blood cells (WBCs) and HF Norm, WBCs and LF/HF, mean platelets volume (MPV) and HF Norm, LF Norm and LF/HF, there was no significant correlation between the hematological and HRV parameters, Table 2
MPV was positively associated with LF Norm (5.373 fL, P .026), and it was negatively associated with HF Norm (−6.828 fL, P = .005), Table 3 and Table 4
Summary
Heart rate variability (HRV) is an informative tool in assessing cardiac autonomic modulations; it has a prognostic value in cardiac diseases, and it is widely used to assess the impact of autonomic imbalance on various diseases such as type 2 diabetes mellitus and obesity,[1,2] coronary heart disease, 3 and inflammatory conditions.[4]. Previous studies have shown altered sympathovagal balance (autonomic modulations) during pregnancy and labor.[5-9]. There are previous publications of blood parameters, for example, hemoglobin,[10] iron deficiency anemia (IDA),[11] red cell distribution width (RDW),[12] mean platelets volume (MPV),[13] folate and vitamin B12 deficiencies,[14] and white blood cells (WBCs).[15,16]. There are no published data on this concept (HRV and hematological parameters) during pregnancy. We have recently observed a high level of anemia (57.7%), an IDA (12.1%) folate and vitamin B12 deficiency among pregnant Sudanese women.[18,19]. We reported different HRV and autonomic modulations in pregnant Sudanese women.[20,21]. The current study was conducted to investigate the associations between HRV, autonomic modulations, and hematological parameters (hemoglobin, WBCs, RDW, and MPV) in normal pregnant Sudanese women We have recently observed a high level of anemia (57.7%), an IDA (12.1%) folate and vitamin B12 deficiency among pregnant Sudanese women.[18,19] we reported different HRV and autonomic modulations in pregnant Sudanese women.[20,21] The current study was conducted to investigate the associations between HRV, autonomic modulations, and hematological parameters (hemoglobin, WBCs, RDW, and MPV) in normal pregnant Sudanese women
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