Abstract
Combination antiretroviral therapy has substantially increased life-expectancy in people living with HIV, but the effects of chronic infection on health-related quality of life (HRQoL) are unclear. We aimed to compare HRQoL in people with HIV and the general population. We merged two UK cross-sectional surveys: the ASTRA study, which recruited participants aged 18 years or older with HIV from eight outpatient clinics in the UK between Feb 1, 2011, and Dec 31, 2012; and the Health Survey for England (HSE) 2011, which measures health and health-related behaviours in individuals living in a random sample of private households in England. The ASTRA study has data for 3258 people (response rate 64%) and HSE for 8503 people aged 18 years or older (response rate 66%). HRQoL was assessed with the Euroqol 5D questionnaire 3 level (EQ-5D-3L) instrument that measures health on five domains, each with three levels. The responses are scored on a scale where a value of 1 represents perfect health and a value of 0 represents death, known as the utility score. We used multivariable models to compare utility scores between the HIV and general population samples with adjustment for several sociodemographic factors. 3151 (97%) of 3258 of participants in ASTRA and 7424 (87%) of 8503 participants in HSE had complete EQ-5D-3L data. The EQ-5D-3L utility score was lower for people with HIV compared with that in the general population (marginal effect in utility score adjusted for age, and sex/sexuality -0·11; 95% CI -0·13 to -0·10; p < 0·0001). HRQoL was lower for people with HIV for all EQ-5D-3L domains, particularly for anxiety/depression. The difference in utility score was significant after adjustment for several additional sociodemographic variables (ethnic origin, education, having children, and smoking status) and was apparent across all CD4 cell count, antiretroviral therapy, and viral load strata, but was greatest for those people diagnosed with HIV in earlier calendar periods. Reduction in HRQoL with age was not greater in people with HIV than in the general population (pinteraction > 0·05). People living with HIV have significantly lower HRQoL than do the general population, despite most HIV positive individuals in this study being virologically and immunologically stable. Although this difference could in part be due to factors other than HIV, this study provides additional evidence of the loss of health that can be avoided through prevention of further HIV infections. UK National Institute for Health Research.
Highlights
The EQ-5D-3L utility score was lower for people with HIV compared with that in the general population
Evidence suggests that people diagnosed with HIV in resource-rich countries have a life expectancy that is almost equivalent to that in people without HIV if they receive appropriate treatment with combination antiretroviral treatment.[1]
The results were similar after removal of all men who have sex with men (MSM) and people who had retired from both datasets and after removal of of homeless people, those who had taken any recreational drugs in the past 3 months, and people who had been ever diagnosed with hepatitis C from ASTRA
Summary
Evidence suggests that people diagnosed with HIV in resource-rich countries have a life expectancy that is almost equivalent to that in people without HIV if they receive appropriate treatment with combination antiretroviral treatment (cART).[1] despite substantial improvements in clinical prognosis, much less is known about the health-related quality-of-life (HRQoL) of individuals with HIV compared with that in the general population.[2,3,4] For example, evidence from studies from the USA show that people with HIV have higher rates of depression than do people without HIV, the effect of HIV status on other domains and overall HRQoL is less clear.[4] HRQoL is a multidimensional concept that incorporates factors such as physical, cognitive, emotional, and social functioning. When measured with socalled utility-based instruments, the information can be used in economic evaluations to help to generate qualityadjusted life-years (QALYs), in which one QALY is equivalent to a year of perfect health.[5]
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