Abstract
BackgroundThe prevalence of depression and anxiety in Chinese population has been increasing in recently years, yet the health-related quality of life (HRQoL) of people with depression and anxiety remains unclear. ObjectiveTo evaluate the HRQoL of individuals with depression and anxiety in China and to explore the factors influencing it. MethodsThe study population was divided into a depressed group and non-depressed group, as well as an anxious group and non-anxious group. The EuroQol five-dimensional five-level questionnaire (EQ-5D-5L) was used to assess HRQoL in these individuals. Regression with the least absolute shrinkage and selection operator (Lasso) was applied separately to the datasets of the depressed and anxious populations for variable selection. A Tobit regression model was then used to analyze the relationship between various influencing factors and HRQoL in both the depressed and anxious populations. ResultsA total of 7920 valid samples were collected from the PBICR database, including 1406 individuals with depression and 933 with anxiety. The HRQoL for individuals with depression and anxiety was estimated at 80.38 ± 17.17 and 80 ± 17.53, respectively. Among those with depression, a significant decrease in HRQoL was observed in individuals with debt (P = 0.021) and ex-smokers (P = 0.022) compared to their control groups. Health literacy (P < 0.001) and self-efficacy (P = 0.008) were identified as significant factors influencing HRQoL. For participants with anxiety, HRQoL was also lower among individuals in debt (P = 0.047) and ex-smokers (P = 0.033) compared to those without debt. Health literacy (P < 0.001) was a significant factor influencing HRQoL. Among individuals with depression (P = 0.006) and anxiety (P = 0.001), males had significantly higher HRQoL than females. ConclusionCommon factors influencing the HRQoL of both individuals with depression and those with anxiety include debt, gender, smoking status, and health literacy. Additionally, self-efficacy is a significant factor affecting the HRQoL of individuals with depression.
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