Abstract
Background: Family-based studies have historically been considered a powerful strategy when understanding the etiologies of human disease, especially those influenced by genetics. A gold standard in family-based study design includes twin studies due to the unique genetic relationships between twin siblings, but these unique familial relationships are relatively rare and difficult to recruit. Herein we demonstrate that electronic health record (EHR) systems across multiple Health Care Systems Research Network (HCSRN) sites can identify twin families. We further show the utility of such twin cohorts in research using twins identified in Marshfield Clinic’s EHR.
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