Abstract
Medical-scientific studies relating to man-made vitreous fibers (MMVF) date from the early 1930s. Extensive health research since that time has dealt with the effects of MMVFs on human, animals, and the environment. Results to date indicate that MMVFs do not produce any chronic adverse health effects in man. Animal inhalation studies demonstrate no appreciable alteration of lung architecture, minimal pleural change, no significant fibrosis, and no tumor development in animals as a result of exposure to man-made vitreous fibers. Even injection of the fibers into the trachea of animals has not produced malignant tumors. Studies of workers exposed to man-made vitreous fibers (fibrous glass) demonstrate no significant difference in lung fiber content or fiber dimensions than shown in nonexposed persons. Such studies further demonstrate no significant malignant respiratory disease. Preliminary results of a current study encompassing 17 man-made vitreous fiber manufacturing facilities and over 16,000 production workers with exposure up to 40 plus years do not indicate any evidence of an excess of malignancies caused by man-made vitreous fibers.
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