Abstract
When a 63-year-old female recovered from diabetic ketoacidosis after the 14th day at the hospital, the value of HDL-cholesterol increased from 71 to 101mg/dl. The activity of her hepatic triglyceride lipase (HTGL) and the activity of her lipoprotein lipase (LPL) decreased. The activity of her HTGL decreased (HTGL: 2.8-2.9μmol·FFA/ml/hr) during her clinical course, while the activity of her LPL and cholesteryl ester transfer protein (CETPA) had been within the normal range (LPL: 11.1-11.2μmol·FFA/ml/hr, CETPA: 30.3%), with good control of blood glucose. Analysis of apolipoprotein A-I or B-100-containing particles was performed by selective affinity columns prepared from the monoclonal antibodies of our patient. The ratio of cholesterol ester (CE) to free cholesterol (FC) in apolipoprotein A-I or B-100 particles increased with poor control of blood glucose, while the ratio decreased with good control of blood glucose. The activity of lecithin-cholesterol acyltransferase decreased from 106 to 66nmol/ml/hr with good control of blood glucose. The mean size of Apolipoprotein A-I particles, which was detected by electron microscopy, was significantly larger in this case (21.2±1.8nm, mean±SEM) than in the control case (13.6±0.2nm).
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