Abstract
<p>This review article aims to provide an update on the sources, pharmaco-logical and biological profile of a β-carboline alkaloid, harmine which is a major bioactive component of various plants mainly Peganum harmala. Harmine’s wide range of pharmacological properties has been well-documented as anti-cancer, anti-inflammatory, anti-oxidant, neuroprotective, anti-depressant, and antimicrobial. Although reported data suggests a multifunctional pharmacological role of harmine but farther experimentation on its molecular mechanism of action, synthetic chemistry approaches, and preclinical studies are yet obligatory to fully uncover its pharmacological efficacy.</p>
Highlights
Natural products have served humanity as a fundamental source of medicine throughout the history of civilization
Structure-activity relationship of harmine derivatives has been established by TD-DFT study (Lamchouri et al, 2013) and this study showed that position-3 and 9 played a crucial role in antitumor as well as neurotoxicity of harmine derivatives
Aggregated data indicated that harmine demonstrates pronounced anti-proliferative effects in MCF-7 cells which are associated with the prohibition of telomerase activity
Summary
Natural products have served humanity as a fundamental source of medicine throughout the history of civilization. Harmine showed anti-proliferative activity towards thyroid TPC-1 cells via down-regulation of Bcl2 dose-dependently (Ruan et al, 2017). An optimized harmine derivative, CM16’s anti-cancer activity was assessed against oligodendroglioma (Hs683), breast adenocarcinoma (MDA-MB231), and melanoma (SKMEL-28) cell lines.
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